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Main exclusion criteria included BMI 20 kg/m, type 1 diabetes mellitus, type 2 diabetes mellitus, previous treatment with insulin or with oral hypoglycemic or insulin-sensitizing agents, history of malignancy, and hypopituitarism

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Introduction Growth hormone (GH) regulation is a subject of considerable interest due to GH's wide roles in organism growth, metabolism, tissue repair, and modulation of IGF-1 levels